Eli Lilly and Company announced Wednesday, Oct. 29 a planned investment of more than $1.2 billion to expand and modernize its Lilly del Caribe manufacturing site in Carolina, Puerto Rico. Photo by Paul Sableman, Wikimedia Commons.

News Release

INDIANAPOLIS — Eli Lilly and Company announced Wednesday, Oct. 29 a planned investment of more than $1.2 billion to expand and modernize its Lilly del Caribe manufacturing site in Carolina, Puerto Rico.

“For over sixty years, Lilly has trusted Puerto Rico, its people, its talent and its potential. Today, that trust translates into new capacity, advanced technologies, investment and long-term economic value for our island,” said Sebastian Negron Reichard, Secretary of the Department of Economic Development and Commerce, Puerto Rico.

This new investment will integrate advanced technologies and expand production capacity within the existing campus to support the company’s growing portfolio of oral solid medicines in cardiometabolic health, neuroscience, oncology and immunology.

The enhanced facility will be among those that will manufacture orforglipron, Lilly’s first oral, small molecule GLP-1 receptor agonist, which the company expects to submit to global regulatory agencies for obesity by the end of this year.

This strategic expansion underscores Puerto Rico’s role in Lilly’s historic manufacturing agenda as a part of the previously announced $50 billion capital investment commitment to expand U.S. manufacturing capacity.

The company recently shared plans to build sites in Texas and Virginia, with two additional locations to be announced in the next few months. These new sites are part of Lilly’s broader efforts to expand existing U.S. manufacturing sites to increase capacity.

“After sixty years, Lilly del Caribe continues to play an important role in making life-changing medicines for people in the U.S. and beyond,” said Edgardo Hernandez, executive vice president and president of Lilly Manufacturing Operations. “Our continued investments in capacity, infrastructure, advanced technologies and highly specialized jobs will further cement the site’s significance in Lilly’s global manufacturing network. Our progress builds on the dedication and expertise of our local team, helping us deliver new medicines for patients around the world.”

This facility will deploy highly advanced technologies in oral solid medicine manufacturing, including dock-to-dock automation and material flow, paperless manufacturing, process analytical technology and spray-dried dispersion, which allows oral medicines to be effectively absorbed.

Lilly estimates that the project will generate up to 1,000 construction jobs and 100 additional high-tech manufacturing positions. The company supports local bioscience growth by offering scholarships for students in engineering, science, technology and business administration.

“This announcement reflects the very essence of our public policy, which is to position Puerto Rico as a strategic hub for advanced manufacturing, innovation and national economic security,” said Jenniffer Gonzalez-Colon, Governor of Puerto Rico.

Gonzalez-Colon continued, “Lilly’s multimillion-dollar expansion is a resounding vote of confidence in our people, our infrastructure and our long-term competitiveness within the U.S. supply chain. It demonstrates that global companies can continue to grow and thrive here, while Puerto Rico contributes in a meaningful way to the resilience of the nation’s most critical industries.”

Construction on the expanded oral solid medicine product manufacturing facility is estimated to begin in 2026, with plans to start producing medicine by the end of 2028.